Flexible delivery: A model for analysis and implementation of flexible programme delivery

The approach to quality and standards in Scotland is enhancement-led and learner-centred. It was developed through a partnership of the Scottish Funding Council (SFC), Universities Scotland, the National Union of Students in Scotland (NUS Scotland) and the Quality Assurance Agency for Higher Education (QAA) Scotland. The Higher Education Academy has also joined that partnership. The Enhancement Themes are a key element of a five-part framework which has been designed to provide an integrated approach to quality assurance and enhancement, supporting learners and staff at all levels in enhancing higher education in Scotland drawing on developing, innovative practice within the UK and internationally. The five elements of the framework are: * a comprehensive programme of subject-level reviews undertaken by the higher education institutions themselves; guidance on internal reviews is published by SFC (www.sfc.ac.uk) * enhancement-led institutional review (ELIR) run by QAA Scotland (www.qaa.ac.uk/reviews/ELIR) * improved forms of public information about quality; guidance on the information to be published by higher education institutions is provided by SFC (www.sfc.ac.uk) * a greater voice for students in institutional quality systems, supported by a national development service - student participation in quality scotland (sparqs) (www.sparqs.org.uk) * a national programme of Enhancement Themes aimed at developing and sharing good practice to enhance the student learning experience, which are facilitated by QAA Scotland (www.enhancementthemes.ac.uk). The topics for the Themes are identified through consultation with the sector and implemented by steering committees whose members are drawn from the sector and the student body. The steering committees have the task of developing a programme of development activities, which draw upon national and international good practice. Publications emerging from each Theme are intended to provide important reference points for higher education institutions in the ongoing strategic enhancement of their teaching and learning provision. Full details of each Theme, its steering committee, the range of research and development activities, and the outcomes are published on the Enhancement Themes website (www.enhancementthemes.ac.uk). To further support the implementation and embedding of a quality enhancement culture within the sector, including taking forward the outcomes of the various Enhancement Themes, a new overarching committee has been established, chaired by Professor Kenneth Miller (Vice-Principal, University of Strathclyde). It has the important dual role of supporting the overall approach of the enhancement themes, including the five-year rolling plan, and of supporting institutional enhancement strategies and management of quality. We very much hope that the new committee, working with the individual topic-based Themes' steering committees, will provide a powerful vehicle for the progression of the enhancement-led approach to quality and standards in Scottish higher education

The reinvigoration of Scottish further education sector: an exploration and analysis of the recent reforms

In July 2012 the Scottish Government published ‘Reinvigorating College Governance: the Scottish Response to The Report of the Review of Further Education Governance in Scotland’. The Report advanced a radical new structure for the Scottish Further Education (FE) sector and the overall impact has been unparalleled, creating seismic transformations to its operating structure and governance. The newly emerging paradigm overturned previous structural and governance arrangements, rescaling the Scottish FE landscape. This paper analyses the recent policy context unfolding within the Scottish FE sector; illuminating the central driving forces and legitimising discourses behind the current restructuring, cognisant of the emergent European educational policy space. It argues that the emerging policy reforms for Scottish FE, commonly referred to as ‘regionalisation’, is simultaneously a continuation and departure from the governing structures set in place in the early 1990s. The paper offers productive ways of framing thinking about the regionalisation of Scottish FE. Consequently, it will be of interest to Scottish Government policy makers and those working within or in partnership with the Scottish FE sector

If I were a grown-up: Children's response to the Rubber Hand Illusion with different hand sizes

During childhood, children’s bodies undergo rapid physical growth, which may affect their ability to accurately perceive their own bodies as well as the external environment. Concurrently, multisensory processes underlying bodily self-consciousness gradually develop. However, little is known of the relation between changes in body size and corresponding update in bodily self-consciousness. In this study, 6- to 8-year-old children experienced the “rubber hand illusion” while watching a regular (child-like) or larger (adult-like) rubber hand being touched either synchronously or asynchronously with their own real hand. We measured proprioceptive drift and subjective ownership as well as changes in weight estimation of objects. Synchronous versus asynchronous visuotactile stroking with both the regular and larger hands caused a change in subjective body ownership but did not make a difference in perceived hand location and weight estimation of objects having the same size but different weight. Intriguingly, simply viewing the regular hand led to greater proprioceptive drift and to overestimation of the objects’ weight relative to the larger hand. In addition, weight estimation was also influenced by hand size after visuotactile stroking. These results demonstrate that visuotactile information modulates the intrinsic properties of body representation in terms of size in children and further corroborate previous findings suggesting late developing optimal calibration of visual and proprioceptive signals

RON5 is critical for organization and function of the Toxoplasma moving junction complex

Apicomplexans facilitate host cell invasion through formation of a tight-junction interface between parasite and host plasma membranes called the moving junction (MJ). A complex of the rhoptry neck proteins RONs 2/4/5/8 localize to the MJ during invasion where they are believed to provide a stable anchoring point for host penetration. During the initiation of invasion, the preformed MJ RON complex is injected into the host cell where RON2 spans the host plasma membrane while RONs 4/5/8 localize to its cytosolic face. While much attention has been directed toward an AMA1-RON2 interaction supposed to occur outside the cell, little is known about the functions of the MJ RONs positioned inside the host cell. Here we provide a detailed analysis of RON5 to resolve outstanding questions about MJ complex organization, assembly and function during invasion. Using a conditional knockdown approach, we show loss of RON5 results in complete degradation of RON2 and mistargeting of RON4 within the parasite secretory pathway, demonstrating that RON5 plays a key role in organization of the MJ RON complex. While RON8 is unaffected by knockdown of RON5, these parasites are unable to invade new host cells, providing the first genetic demonstration that RON5 plays a critical role in host cell penetration. Although invasion is not required for injection of rhoptry effectors into the host cytosol, parasites lacking RON5 also fail to form evacuoles suggesting an intact MJ complex is a prerequisite for secretion of rhoptry bulb contents. Additionally, while the MJ has been suggested to function in egress, disruption of the MJ complex by RON5 depletion does not impact this process. Finally, functional complementation of our conditional RON5 mutant reveals that while proteolytic separation of RON5 N- and C-terminal fragments is dispensable, a portion of the C-terminal domain is critical for RON2 stability and function in invasion

Effect of alirocumab on mortality after acute coronary syndromes. An analysis of the ODYSSEY OUTCOMES randomized clinical trial

Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; Pinteraction=0.007). In the alirocumab group, all-cause death declined wit h achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for ≥3 years, if baseline LDL-C is ≥100 mg/dL, or if achieved LDL-C is low. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402

A model for effective implementation of flexible programme delivery

The model developed here is the outcome of a project funded by the Quality Assurance Agency Scotland to support implementation of flexible programme delivery (FPD) in post-compulsory education. We highlight key features of FPD, including explicit and implicit assumptions about why flexibility is needed and the perceived barriers and solutions to implementing it. Our model addresses issues in implementing FPD at three levels within institutions: institutional, operational, and teaching and learning management, supporting strategic alignment at all three levels. It has been used to analyse four case studies at the University of Dundee and the UHI Millennium Institute